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قديم 24-11-2012, 10:30 AM   المشاركة رقم: 5
معلومات العضو
آية بسمله

إحصائية العضو







 
 


التوقيت

التواجد والإتصالات
آية بسمله غير متواجد حالياً

كاتب الموضوع : آية بسمله المنتدى : صيدلية أحباب الحسين
افتراضي

Chloramphenicol

Trade name: Chloromycetin
Class: antibiotic
Pregnancy: Category C

Action: it inhibits protein synthesis in bacteria by binding to ribosome

Uses
Not to be used for trivial infections as prophylaxis of infection
Cold, throat infections or flu
Treatment of choice for typhoid fever not for carrier state
Meningitis due to hemophilus influenza, pneumocoeoi or
Miningococei
Skin infections (topically)
Brain abscesses

Dose : by mouth or by intravenous injection or infusion, 50 mg/kg daily in 4 divided doses (exceptionally, can be doubled for severe infections such as septicemia and meningitis, providing high doses reduced as soon as clinically indicated); Child, haemophilus epiglottitis and pyogenic meningitis, 50–100 mg/kg daily in divided doses (high dosages decreased as soon as clinically indicated); Infants under 2 weeks 25 mg/kg daily in 4 divided doses
2 weeks–1 year 50 mg/kg daily in 4 divided dose

Contraindications
Hypersensitivity to chloramphenicol
Pregnancy
Nursing mothers
Renal and hepatic failure

Side effectsA plastic anemia, pancytopnea, nausea, vomiting abdominal distention, “progressive pallid cyanoses, ashen gray color, tachypnea , vasomotor collapse & death”, Gray syndrome in infants, super infections

Nursing considerations

Administer IV as 10% solution over at least 1 min
Note any history of hypersensitivity & other contraindications, & if
Client takes antidiabetic or other medications that cause bone marrow depression
Neonates should be observed closely (greater hazards of toxicity)
Arrange for further hematologic studies to be conducted every 2 days to detect early signs of bone marrow depression
The drug should be taken at regular intervals to be most effective
The drug should be taken 1 hr before or 2 hr after meals - if GI upset Occurs it could be taken with the food












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