Chlorpromazine
Trade name: Largactil
Class: Antipsychotic, phenothiazine
Pregnancy: Category C
Action: Act by blocking dopamine receptors It has significant antiemetic effect, hypoteinsive, sedative & anticholenergic effect
Uses
Acute & chronic psychosis (such as schizophrenia, mania & manic
Depression
Preanasthetic
Intractable hiccoughs
Nausea & vomiting
Dose : by mouth psychomotor agitation, excitement, and violent or dangerously impulsive behavior initially 25 mg 3 times daily (or 75 mg at night), adjusted according to response, to usual maintenance dose of 75–300 mg daily
Intractable hiccup, oral 25–50 mg 3–4 times daily
By deep intramuscular injection, (for relief of acute symptoms, 25–50 mg every 6–8 hours; Child, 1–5 years 05 mg/kg every 6–8 hours (max 40 mg daily); 6–12 years 05 mg/kg every 6–8 hours (max 75 mg daily)
Induction of hypothermia (to prevent shivering), by deep intramuscular injection, 25–50 mg every 6–8 hours; Child 1–12 years, initially 05–1 mg/kg, followed by maintenance 05 mg/kg every 4–6 hours
Contraindications
Sever depression, coma
Bone marrow depression
Patients with history of seizures & on anticonvulsant therapy
Hepatic & renal diseases
Prostatic hypertrophy
Dehydration - glaucoma, measles
Side effects
Depression, dizziness, seizures, gynecomastia Orthostatic hypotension, bronchospasm, larlynyospasm tardive dyskinesia, photosensitivity, leukopnea, aplastic anemia, and dry mouth
Nursing considerations
Shouldn’t be used to treat nausea & vomiting in children less than 6 months of age
Should avoid getting solution on hands or clothing - it will cause dermatitis
Solutions with marked discoloration should be discarded
Note any history of seizures
Take liver & kidney function test periodically
******** & rotate injection sites
Report side effects immediately
Determine age of male patients & assess for prostatic hypertrophy