Clindamycin phosphate
Trade name: Dalacin
Class: antibiotic, clindamycin
Pregnancy: Category B
Action: suppress protein synthesis by microorganisms by binding to ribosomes It is both bacteriostatic & bactericidal
Uses
Serious respiratory tract infections (lung abscess, pneumonia)
Serious skin infections
Septicemia
Osteomyelitis caused by staphylococci
Used topically for inflammatory acne vulgaris
Dose : by mouth, 150–300 mg every 6 hours; up to 450 mg every 6 hours in severe infections; CHILD, 3–6 mg/kg every 6 hours
NB
Patients should discontinue immediately and contact doctor if diarrhea develops; capsules should be swallowed with a glass of water
By deep intramuscular injection or by intravenous infusion, 06–27 g daily (in 2–4 divided doses); life-threatening infection, up to 48 g daily; single doses above 600 mg by intravenous infusion only; single doses by intravenous infusion not to exceed 12 g
CHILD over 1 month, 15–40 mg/kg daily in 3–4 divided doses; severe infections, at least 300 mg daily regardless of weight
Contraindications
Hypersensitivity
Minor bacterial infections
Pregnancy
Side effects
Nausea, vomiting, diarrhea, abdominal pain, tenesmus
Loss of weight, pseudo membranous colitis, skin rashes
Hypotension
Thrombophlebitis following IV use
Nursing considerations
Give parenteral drug to hospitalized client only
Dilute IV injections If IM, inject medication deeply
Don’t refrigerate solution because it becomes thick
Before use, take full history & not signs of allergy
Be prepared to manage colitis which can occur 2-9 days or several weeks after initiation of therapy Which includes: fluids, electrolytes, Protein supplement, corticosteroids, and Vancomycin as ordered
During IV administration, observe for signs of hypotension
Administer only on an empty stomach With a full glass of water to prevent esophageal ulceration