Ceftriaxone
Trade name: Rocephin
Class: Antibiotic "cephalosporines" third-generation
Pregnancy: Category B
Action: Bind to bacterial cell wall membrane, causing cell death
Uses
Pneumonia, UTI, infections of skin, bone & abdomen Meningitis, bacterial septicemia, pre-op prophylaxis
Dose
by deep intramuscular injection, or by intravenous injection over at least 2–4 minutes, or by intravenous infusion, 1 g daily; 2–4 g daily in severe infections; intramuscular doses over 1 g divided between more than one site
Neonate by intravenous infusion over 60 minutes, 20–50 mg/kg daily - max 50 mg/kg daily
Infant and child under 50 kg, by deep intramuscular injection, or by intravenous injection over 2–4 minutes, or by intravenous infusion, 20–50 mg/kg daily; up to 80 mg/kg daily in severe infections; doses of 50 mg/kg and over by intravenous infusion only; 50 kg and over, adult dose
Uncomplicated gonorrhea, by deep intramuscular injection, 250 mg as a single dose
Surgical prophylaxis, by deep intramuscular injection or byintravenous injection over at least 2–4 minutes, 1 g at induction; colorectal surgery, by deep intramuscular injection or by intravenous injection over at least 2–4 minutes or by intravenous infusion, 2 g at induction; intramuscular doses over 1 g divided between more than one site
Contraindications
Hypersensitivity to cephalosporin or Penicillin ,renal failure
Side effects
Nausea, vomiting, diarrhea, anorexia, abdominal pain, flatulence, skin rashes super-infection, heartburn, sore mouth, bone marrow depression
Nursing considerations
IM injection should be deep into the body of large muscle
IV injection should be diluted
For stability of solution the package insert should be checked carefully
Dosage should be maintained for at least 2 days after symptoms of infection have disappeared (usual course is 4-14 days